Chapter 63: Chapter 60: The World’s Strongest in 30 Minutes! (3rd Update!!!)
After organizing his thoughts, Xu Yun returned to the bookshelf to search for the books he needed.
Unlike before, the two girls who mentioned Professor Lu, possibly from the physics department, were nowhere to be seen. He didn’t know if they had found the Newton materials they were looking for.
By this time, Xu Yun had somewhat realized that his earlier behavior was indeed a bit odd. Fortunately, Ke Da had a clear academic atmosphere. Otherwise, at some other universities, he might have metaphorically ’had his neck cut’ before finishing his sentence.
Xu Yun then shook his head, pushed these thoughts aside, and spent half an hour gathering three books and several journals.
After completing the borrowing process, he returned to his own little nook.
Previously mentioned, mammalian sodium channels have 9 subtypes, namely NaV1.1-NaV1.9.
Currently, there are in-depth biological studies on six subtypes, with typical representatives in technical application being some Class I antiarrhythmic drugs.
For example, quinidine, lidocaine, and propafenone work by blocking sodium channels.
Similarly, when bitten by spiders, venomous snakes, scorpions, Enchanting Demons, and such, the toxins interact with sodium ion channels, resulting in adverse effects.
As for insect sodium channels...
The situation is more complex.
In reality, insects have only one or two voltage-gated sodium ion channel α-subunit genes, but two types of post-transcriptional modifications—namely, alternative splicing and RNA editing—lead to functional diversity of insect sodium ion channels.
In addition, the insect β auxiliary subunits TipE and TEH1-4 also play important roles in the expression and regulation of sodium ion channels.
Therefore, the binding formula Xu Yun needed to deduce was not merely about piecing proteins together; the binding speed to specific receptors was the main issue.
This is akin to the blue pill, where taking effect in two hundred minutes and two minutes are completely different concepts.
More specifically, the crystal structure and modeling issues of NDT-A needed to be considered.
Currently, many teams in the biology field are conducting research on insect sodium channels, but the results generally lack significant breakthroughs, being scattered and hard to form a complete modular chain.
However, this coincidentally provided Xu Yun with opportunities for multi-angled reference material. More importantly...
He still had a trump card up his sleeve.
At this moment, Xu Yun sat at his desk, gently spinning a small black card in his hand.
The card was about the size of a bank card, with a full metallic feel, and on it was the portrait of Little Niu, eyes sharp, confident, and flamboyant.
That’s right.
This was one of the rewards of a rookie task, a thirty-minute Little Niu—no, Experience Card!
According to Xu Yun’s intuition, as long as he activated the card with a mental note, he could possess Little Niu’s thinking ability at the age of 22 for thirty minutes.
How strong was the ability of Little Niu at 22 was briefly mentioned before, so it won’t be elaborated here.
"Tsk, it’s a pity it’s only half an hour, still a bit short."
Xu Yun rubbed his temples in mild annoyance and picked up paper and pen to make some arrangements:
"The expression of TipE definitely shouldn’t consume the Experience Card, and using action potential conduction in peripheral nervous system neurons is best avoided since there are plenty of relevant papers....."
"The binding sites have to use, there are over two thousand harmonized ones..."
Xu Yun thus wrote, deliberated, carefully considering, spending a full hour finally determining the key nodes:
First, the expression of TipE, the open conformation structure, and the derivation of the β1-β2 chain adjacent subunits should be completed independently.
Secondly, the binding sites of sodium ion channels with imidacloprid, the cytoplasmic region’s architecture should be handed over to Little Niu.
The summary of the final binding formula should then be compiled by himself.
Having confirmed these steps, Xu Yun immediately began the calculations.
Currently, most of the research papers on insect sodium ion channels were submitted to the "Annual Review of Entomology," so among the materials Xu Yun brought back, four were back issues of this journal.
Moreover, coincidentally, TIPE2 is a novel immune checkpoint molecule for NK cells, and Tian Liangwei happens to be an expert in NK cells, thus the first problem was not particularly difficult to solve, it’s just that no one had rerouted the receptor protein there.
It’s like online literature, where the unique styles of Chen Dong and Feng Huo are hard to imitate, but genres like sign-in articles or courtyard stories weren’t invented from nothing, it’s just no one thought in those directions initially.
Once someone discovered such a genre, numerous imitators would quickly appear in the recommendation list, the principle is the same.
Swiftly, Xu Yun locked onto an authoritative paper:
"DOI: 10.33086/jhs.v10i2.136.... Hmm, the author is a senior who graduated a long time ago? A Stanford associate professor.....
Grass bug receptors..... Subtype potential difference of 2.345, the American cockroach’s is 2.344, clearly a similar expression method, excellent, this is the one!"
Presently, Xu Yun’s comprehensive ability is roughly equivalent to an associate professor at Ke Da, which is above associate high, barely equivalent to a full professor in niche disciplines, yet still a distance from mainstream subject’s full professor level.
There are plenty of domestic full professor ’monsters’ around the age of 30, so Xu Yun had originally set his goal to strive for being a full professor at Ke Da by age 28, much like the path of the Nankai academician Cao Xuetao.
Of course.
Now, with the gradual manifestation of the halo effect, Xu Yun’s subsequent trajectory would definitely change, but as of now, his capability was still at the associate full level, making it not difficult to independently derive compound formulas with reference papers at hand.
Then Xu Yun, using data from this paper, successively derived three sets of data for the first node.
"Phew."
Then Xu Yun took a deep breath, solemnly picked up Little Niu’s Thought Experience Card, and mentally whispered.....
"Activate!"
Whoosh——
As the command was issued, the Experience Card instantly turned into a streak of flowing light and vanished into his mind.
Xu Yun’s temples cooled briefly, and in less than a moment, a profoundly mysterious feeling immediately filled his brain.
How to say.....
It felt as if everything became clear.
Xu Yun’s gaze accidentally skimmed over a Penguin group called ’Qidian Group Seven Premium Group’, where an author named ’The Tenth Small Horn’ had just posted a series of mysterious codes.
Even with just a quick glance, Xu Yun memorized all the numbers in that string of codes:
"magnet:?xt=urn:btih:....."
But he quickly returned to his senses and focused his attention back on the problem at hand.
At this moment, the numerous challenges that initially left him at a loss, Xu Yun, with just a bit more thinking, found several plausible deduction directions.
These deduction directions were not so exaggerated as to immediately reveal the results, but some key aspects already had solutions to break through.
This is the genius of Little Niu at 22, who laid down the cornerstone of modern mathematical physics in 18 months!
One might even say, for the next thirty minutes, Xu Yun’s cognitive abilities momentarily ascended to the world’s top tier, or even to the unprecedented level of...
The strongest!
After an initial half-minute of adaptation, Xu Yun immediately picked up pen and paper, swiftly calculating the binding formula problem.
"Action potential threshold at 130mV, it should be possible to reach 133mV..."
"The process of depolarization of the binding protein axon should have... hmm, five types, not sure which one Old Qiu and his team’s receptor connects to, forget it, let’s calculate them all....."
"Points stimulation of IL-12, IL-15, and IL-18... let’s use the University of Pennsylvania’s paper as a base for exploration, one of Teng School’s, still Professor James Alwine’s....."
Just like that.
Xu Yun flipped through and computed data at a pace akin to quantum wave speed reading, while time gradually ticked away second by second.
Three minutes.....
Five minutes.....
Ten minutes.....
Twenty minutes.....
By the twenty-sixth minute, Xu Yun’s deduction reached its crucial moment.
The veins on his forehead bulged, breathing rapid, adjusting his posture, readying for the final sprint at the unsealed breach.
Three minutes later, in the final seconds approaching the time limit.
Xu Yun exhaled a deep breath and heavily wrote down a cell segment on paper:
MC38.
Afterward, he tossed the pen aside, a previously unfelt sense of fatigue surged up:
"Goodness..."
"Finally..."
"It’s done!"